Acting GWS captain Toby Greene kicked a monster 67-metre goal and got reported as the Giants condemned Carlton to a season-high 36-point loss.
In Saturday's earlier matches, the Brisbane Lions survived a stern test to beat North Melbourne by 23 points and Port Adelaide outclassed Gold Coast in a 50-point triumph.
Five straight goals either side of half-time propelled GWS to a 39-point lead on its way to a 16.6 (102) to 9.12 (66) win at Giants Stadium, which lifted them one spot to ninth on the ladder and within two points of eighth-placed Richmond.
The Blues, who slumped to a third straight loss and are being subjected to a mid-season review by an external panel, looked toothless in the first half when they kicked just three goals.
They showed much more fight and better ball movement after the early stages of the third quarter.
They kicked four straight goals and got to within 12 points in the third and fourth quarters, but fell away badly in the final stages, a depressingly familiar pattern for Carlton fans.
Key forward Harry McKay, who did not touch the ball in the first quarter and just twice to half-time, was prominent in the Blues' fightback.
He kicked three goals, a few days after the Coleman Medal leader signed a contract extension.
But GWS had more weaponry up forward and kicked five of the last six goals.
Jeremy Finlayson kicked five goals and Greene four.
Greene sent the majority of the small crowd into raptures after the first-quarter siren, when he hit the target with a booming kick from just inside the centre circle.
He was reported for striking Nic Newman in an off-the-ball incident early in the third quarter, appearing to make contact with his opponent's ribs.
Midfield bulls Jacob Hopper and Tim Taranto were very productive and effective for GWS.
Underlining McKay's lack of early impact, he took a mark inside the Blues forward 50, but fumbled the ball over the boundary line after he played on quickly.
All of Carlton's first three goals came from free kicks awarded to Matthew Owies and Lachie Fogarty in the first quarter, and McKay in the second.
GWS made 37 more tackles and proven tagger Matt de Boer limited the influence of Carlton's midfield big guns Sam Walsh and Patrick Cripps, although each won 11 contested possessions.
Eddie Betts tallied just five disposals and was held goalless, while former Giant Zac Williams recorded just 11 disposals.
Adding to the Giants' pleasure were first AFL goals for both Isaac Cumming and Kieren Briggs, with the former doing it in his 23rd match and the latter in just his second.
Owies kicked two goals, the fifth time this season he has booted two or more in a match.